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Nerve cells communicate with one another via signaling molecules. The rule is: the more of these molecules, the stronger the signal. Drugs and diseases influence these processes and can weaken or strengthen the signal. Together with colleagues of Einstein BIH Visiting Fellow Thomas Südhof from Stanford University, who won the Nobel Prize in Medicine in 2013 and is supported by Stiftung Charité, Charité researchers have now been able to explain how these communication “modulators” work. They have published their results in the scientific journal Cell.
Human deep sleep is characterized by rhythmical brain waves. In deep sleep millions of cerebral neurons are active in synchrony and generate slow, rhythmical brain waves. After a long time awake, the same brain activity pattern can be measured as a sign for fatigue. A NeuroCure research team led by Dr. David Owald now observed those waves within fruit flies.
Jens Kremkow, ECN-Member will have his project in visual perception brought to fruition at the Allen Institute for Brain Science in Seattle; its results will be accessible to all interested scientists. The project is part of a new endeavor called OpenScope – a project spanning various institutions that was begun in 2018 and modeled after shared astronomy observatories that became the seat of major findings about the physical universe.
Dysfunctions in the maternal immune system that occur during pregnancy could possibly lead to impaired brain development in the unborn child. This is suggested by studies by the German Center for Neurodegenerative Diseases (DZNE) and Charité – Universitätsmedizin Berlin, which are based on laboratory experiments and additional findings in humans.
All around the world children play hide and seek. But do animals do so too? In a recent study, scientists from the Einstein Center for Neurosciences Berlin and the Humboldt University Berlin show that rats can quickly learn a rat-human version of the game and can easily switch between different roles – hiding and searching. The scientists suspect that hide and seek has its origins much earlier in evolution than previously thought. The study has been published on September 13, 2019 in the journal Science.
Prof. Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and member of the NeuroCure Cluster of Excellence, has been elected to the renowned "Academia Europaea".
For his research on memory, Dr. rer. nat. Nicolas Schuck, Max Planck Institute for Human Development, will receive a Starting Grant from the European Research Council (ERC). The grant is endowed with approximately 1.5 million euros.
The activation of mTor complex 1 in the cell is central to many vital processes in the body such as cell growth and metabolism. Overactivity of this signalling pathway can result in diseases such as in diabetic insulin resistance and cancer. A team led by the scientist Volker Haucke (Leibniz – Forschungsinstitut für Molekulare Pharmakologie and Freie Universität Berlin) has now discovered how inactivation of a certain lipid kinase promotes mTor complex 1 activity, and may therefore constitute a new point of attack for the treatment of diabetes and cancer. The results have just been published in the renowned journal Nature Cell Biology.
Major award for Berlin: The Berlin University Alliance has won funding as a group in the Universities of Excellence funding line of the German federal and state governments’ Excellence Strategy. The German Council of Science and Humanities announced the decision on July 19, 2019, in Bonn. The four Berlin partners – Freie Universität Berlin, Humboldt-Universität zu Berlin, Technische Universität Berlin, and Charité – Universitätsmedizin Berlin – submitted a joint proposal entitled Crossing Boundaries toward an Integrated Research Environment and in a highly competitive process were able to convince the reviewers of its feasibility.
We are pleased to announce that Genevieve Yvon-Durocher, Neurasmus and MedNeuro MSc student won the prize for the best thesis defence during this year's annual meeting of the Neurasmus MSc program. The thesis was done in the lab of David Owald (ECN and NeuroCure) focusing on the role of slow wave delta oscillations in sleep homeostasis in Drosophila melanogaster.
Upcoming Saturday June 22, the next Soapbox Science Berlin event will take place at Alexanderplatz In this novel public outreach platform that promotes women scientists and transforms public spaces into arenas for learning and scientific debate, twelve female researchers will step onto their soapboxes to give talks to the public.
Open Innovation and Open Science are increasingly recognized as the central pillars of future research and innovation systems. A better integration of Open Innovation and Open Science into research will become an important driving force to increase scientific novelty and impact, calling for the creation of novel playgrounds for Open Innovation in Science (OIS).
We’d like to invite you to one of the smartest nights of the year – the Long Night of the Sciences (LNDW).
On June 15th, from 5pm until midnight, over sixty scientific institutions across Berlin and Potsdam-Telegrafenberg are opening their doors to the public, offering more than 100 hands-on venues with the motto marvel at, touch and understand.
Approximately 10 million people in Germany are addicted to either alcohol, tobacco, prescription drugs or illegal drugs. A small percentage manage to overcome their addiction without any outside help. How they manage to do so is being explored by the new transregional Collaborative Research Center (SFB/TRR) ‘Losing and Regaining Control in Addiction – Development, Mechanisms and Interventions’, which is being led by Charité – Universitätsmedizin Berlin.
In the context of this year’s day of the biosciences, the University of Regensburg confers the honoris causa to Prof. Dr. Peter Hegemann for his outstanding work on photoreceptors and their implications in Optogenetics.
On Wednesday, May 22 the National Academy of Sciences introduces the new members in the field of life sciences. Honouring her scientific achivements, Prof. Dr. Carmen Birchmeier is getting one of the highest scientific Awards granted by a german Institution.
The "Berlin Brains" lecture series at URANIA is organized jointly by the Cluster of Excellence NeuroCure, and the Einstein Center for Neurosciences Berlin. This lecture series increases the visibility of the neurosciences in Berlin and highlights the funding invested in these areas. In 2019 female neuroscientists from Berlin will present their work.
The American Academy of Arts & Sciences awards the Rumford Prize to Peter Hegemann, Ernst Bamberg, Ed Boyden, Karl Deisseroth, Gero Miesenböck and Georg Nagel for the invention and refinement of optogenetics. The Rumford Prize was presented during the Academy’s Annual Awards Ceremony on April 11, 2019, at the Academy’s headquarters in Cambridge, Massachusetts and is one of the oldest scientific prizes in the United States founded in 1796.
How can we improve the identification and prompt diagnosis of genetic diseases? A new Research Unit at Charité – Universitätsmedizin Berlin will set out to identify and reliably interpret important non-coding sections of our genomes in the hope of finding the diagnosis for unsolved diseases. The researchers’ objective is to develop software capable of analyzing whole-genome data in the clinical setting. The Research Unit, which is being funded by the German Research Foundation (DFG), will receive approximately €3.5 million over a period of three years.
How might we further improve deep brain stimulation and its use in the treatment of neurological disorders? And how does the nervous system regulate both protective and chronic immune responses? These questions are at the heart of investigations by two research teams headed by Dr. Andreas Horn and Dr. Christoph Klose at Charité - Universitätsmedizin Berlin. Funded by the German Research Foundation (DFG), these two independent Emmy Noether Junior Research Groups are set to receive more than €1.7 million for a period of three years, with potential for extension.
The international week of the Brain - the “Brain Awareness Week” - took place from March 11th - 17th 2019. This year once again the Einstein Center for Neurosciences Berlin and NeuroCure presented together with various research institutions in Berlin a diverse program including lectures, workshops and movies for people of all ages.
In the first call for proposals in 2018, all five institutions have now approved 29 research projects in the humanities, social sciences, medicine, and the STEM subjects of science, technology, engineering, and mathematics. The Berlin partners and the University of Oxford are funding the projects with 450,000 euros.
The Brain Awareness Week (BAW) is an international campaign to increase public awareness of the progress and benefits of current brain research, ranging from microscopical cells to complex psychiatric disorders.
Prof. Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) receives the Feldberg Prize 2020, which is awarded annually by the Feldberg Foundation for anglo-german scientific exchange. The aim is to promote scientific exchange between British and German researchers in the field of experimental medicine, in particular in the disciplines of physiology and pharmacology.