How SARS-CoV-2 reaches the brain

Using post-mortem tissue samples, a team of researchers from Charité – Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does. The results, which show that SARS-CoV-2 enters the brain via nerve cells in the olfactory mucosa, have been published in Nature Neuroscience*. For the first time, researchers have been able to produce electron microscope images of intact coronavirus particles inside the olfactory mucosa.

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A new generation of optogenetic tools for research and medicine

The European Research Council (ERC) is providing 10 million euros in funding for an interdisciplinary, collaborative project to structurally and biophysically analyze selected photo-receptors and develop them into “OptoGPCRs”, light-controlled molecular switches with a wide range of applications in biology and medicine. 

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Surprising insights into the role of autophagy in neurons

It appears that autophagy protects our neurons in the brain, but evidently for entirely different reasons than previously assumed, as researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Charité in Berlin have now shown. These fundamentally new findings have now been published in the prestigious journal “Neuron”.

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Falling Walls Winner

We are Falling Walls Finalists! Watch our science breakthrough in the Science and Innovation Management Category here: Enable the next impact-driven generation of scientists
Register for free to join the virtual showcase of the Science Breakthroughs of the Year from 1 – 10 November 2020

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International Festival of Science in Berlin and Remote

Ten days of research, innovation and international exchange - Berlin Science Week and Falling Walls invite you to a Remote World Science Summit this year. With more than 200 virtual discussion events, workshops, exhibitions and performances, the organizers defy the pandemic and want to promote a deeper understanding of the world. Neuroscientists will discuss, for example, how to deal with dementia.

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Emmanuelle Charpentier honoured with the 2020 Nobel Prize in Chemistry

The Royal Swedish Academy of Sciences has awarded this year’s Nobel Prize in Chemistry to NeuroCure PI Prof. Dr. Emmanuelle Charpentier, Scientific and Managing Director of the newly established Max Planck Unit for the Science of Pathogens in Berlin for her groundbreaking work on the CRISPR-Cas9 gene editing technology. She shares the prize with Jennifer Doudna from the University of California, Berkeley, USA.

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Organoids and sequencing team up for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative’s Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

Read more … Organoids and sequencing team up for ALS research