"In-Vitro Characterization of 5-HT2A Receptor Agonists by NanoBiT Assays"

As part of the ongoing Student/Postdoc-Run Speaker Series (SPRSS), and on behalf of the Neural Mechanisms of Psychedelic Drug Action Group, Dr. Eline Pottie from Ghent University will give a talk titled "In-Vitro Characterization of 5-HT2A Receptor Agonists by NanoBiT Assays."

Abstract: The serotonin 2A receptor (5-HT2AR) is involved in a wide variety of physiological and pathological functions. Besides that, it is the main pharmacological target of serotonergic psychedelics, among which the prototypical psychedelic substance LSD and psychedelic new psychoactive substances (NPS). Because NPS are often scarcely described, we aimed at setting up in vitro assays to assess the in vitro pharmacological activity of these substances at the 5-HT2AR, and assess whether or not the in vitro parameters correlate with described doses. As a second aim, we set out to verify if structurally closely related ergolines, of which some are reportedly psychedelic and others are not, showed different results in the assays.

For information on other talks organized by the 'Neural Mechanisms of Psychedelic Drug Action' Student/Postdoc-Run Group, view the program overview here.